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Home / Proteins & Peptide

Recombinant Human Pro-Neuregulin-1/NRG1-??1 Protein (aa 1-246, His Tag)(Active)

SKU : BHP10303948

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH032940
Alternative Names	Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF;
Reconstitution	Please refer to the printed manual for detailed information.
Background	neuregulin-1 (heregulin-1;NRG1) is a member of neuregulin family; which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I; type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors; concomitantly recruits ERBB1 and ERBB2 coreceptors; resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
Reactivity	Human
Tag	N-6His
Description	Recombinant Human Neuregulin-1 beta is produced by our E.coli expression system and the target gene encoding Met1-Lys246 is expressed with a 6His tag at the N-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of 4mM HCl.
Host	E.coli
Accession Number	Q02297-6
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Immobilized Human NRG1Beta-His at 10ug/ml(100 ul/well) can bind Human HER3-Fc(Cat: PKSH033438). The ED50 of Human Glypican-3-His is 5.18 ug/ml.
Mol Weight	29.0 kDa
Mw(kda)	29.0 kDa

Sequence Info	Met 1-Lys246

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303948	PKSH032940	10ug	$62		Add to Cart
BHP10303948	PKSH032940	50ug	-		Add to Cart

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