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Home / Proteins & Peptide

Recombinant Human pro-IGF-II

SKU : BHP10900207

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z103025
Description	Insulin-like growth factor 2 (IGF2) is one of the mitogenic, polypeptide growth factors that belongs to the insulin family, due to its structural and functional similarity to insulin. IGF2 is mainly produced in the liver and several other tissues at certain times. IGF2 expression can be found in many tissues usually with autocrine, paracrine and endocrine functions, and mainly acts as a growth promoting hormone during gestation. The pro-IGF-II proteins make up 10-20% of circulating IGF2 and is converted to mature IGF2 by sequential cleavage at amino acids 104, 87 and 67. Pro-IGF-II proteins are secreted by some tumour cell lines and levels are elevated in non-islet cell tumour hypoglycaemia. Recombiant Human pro-IGF-II is expressed in human 293 cells as a monomeric glycoprotein with a molecular mass of 25 kDa.
Alternative Names	Pro-Insulin like Growth Factor-2 ; pro-IGF2.
Quantity	10 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose-dependent stimulation of the proliferation of MCF-7 cells (human breast cancer cell line) was found to be ≤ 50 ng/mL.

Weight	25 kDa, monomer, glycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 10 mM Tris-HCl pH 7.4 + 350 mM NaCl
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900207	Z103025	10µg	$164.44		Add to Cart

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