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Home / Proteins & Peptide

Recombinant Human PRKG1 (N-GST tag)

SKU : BHP10901223

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500330
Description	PRKG1 is a homodimer, with each monomer containing a regulatory cGMP-binding domain and a catalytic domain . By Northern blot analysis PRKG1 was shown to be expressed at highest levels in bladder, uterus, adrenal gland, and fallopian tube. PRKG1 plays an important stimulatory role in platelet activation . Expression of recombinant PRKG1 in a reconstituted cell model enhanced von Willebrand factor-induced activation of the platelet integrin alpha-IIb/beta-3. Prkg1 knockout mice showed impaired platelet responses to VWF or low doses of thrombin and prolonged bleeding time. Human platelet aggregation induced by VWF or low-dose thrombin was inhibited by PRKG1 inhibitors but enhanced by cGMP.
Alternative Names	cGKI-alpha ; DKFZp686K042 ; PGK ; CGKI ; PRKG1B ; PRKGR1B ; FLJ36117 ; MGC71944 ; cGKI-BETA
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of PRKG1 was determined to be 780 nmol /min/mg as per activity assay protocol.

Weight	100.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901223	Z500330	10µg	$361.11		Add to Cart

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