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Home / Proteins & Peptide

Recombinant Human Poly(A)-specific ribonuclease PARN(PARN)

SKU : BHP10502423

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP017456HU
Alternative Names	Deadenylating nucleaseDeadenylation nucleasePolyadenylate-specific ribonuclease
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early bryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain prature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elents (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the roval of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Poly(A)-specific ribonuclease PARN; EC= 3.1.13.4; Alternative name(s): Deadenylating nuclease; Deadenylation nuclease; Polyadenylate-specific ribonuclease
Expression Region	1-639aa
Mol Weight	75.5kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	Dyskeratosis congenita, autosomal recessive, 6 (DKCB6); Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 4 (PFBMFT4)
Subcellular Location	Nucleus, Cytoplasm, Nucleus, nucleolus
Uniprot	O95453, O95453
Database Links	HGNC:8609 OMIM:604212 KEGG:hsa:5073 STRING:9606.ENSP00000387911 UniGene:Hs.253197
Function	3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.
Protein Families	CAF1 family
Research Area	Transcription
Tissue Specificity	Ubiquitous.
Weight	75.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502423	CSB-YP017456HU	500ug	$1298		Add to Cart
BHP10502423	CSB-YP017456HU	100ug	$470		Add to Cart
BHP10502423	CSB-YP017456HU	20ug	$250		Add to Cart

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