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Home / Proteins & Peptide

Recombinant Human Peroxisomal biogenesis factor 19(PEX19) (Active)

SKU : BHP10506511

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP017802HU
Alternative Names	33 kDa housekeeping protein, Peroxin-19, Peroxisomal farnesylated protein
Relevance	Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized ABCD1 at 5 μg/ml can bind human PEX19, the EC50 of human PEX19 protein is 22.96-33.00 μg/ml.
Expression Region	2-296aa
Mol Weight	59.3kDa
Protein Description	Full Length of Mature Protein

Involvement In Disease	Peroxisome biogenesis disorder complementation group 14 (PBD-CG14); Peroxisome biogenesis disorder 12A (PBD12A)
Subcellular Location	Cytoplasm, Peroxisome membrane, Lipid-anchor, Cytoplasmic side
Uniprot	P40855
Database Links	HGNC:9713 OMIM:600279 KEGG:hsa:5824 STRING:9606.ENSP00000357051 UniGene:Hs.517232
Function	Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
Protein Families	Peroxin-19 family
Research Area	Tags & Cell Markers
Tissue Specificity	Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form.

Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Storage Buffer	Tris-based buffer，50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10506511	CSB-EP017802HU	1mg	$1812		Add to Cart
BHP10506511	CSB-EP017802HU	100ug	$419		Add to Cart
BHP10506511	CSB-EP017802HU	20ug	$224		Add to Cart

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