PDHK4 or Pyruvate Dehydrogenase Kinase 4 is a member of the PDHK family that phosphorylate and inactivate the Pyruvate Dehydrogenase (PDH) . PDH is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDHK4 upregulation in adipocytes participates in the hypolipidemic effect of thiazolidinediones through modulation of glyceroneogenesis . PDHK4 expression is strongly and selectively induced by Rosiglitazone in a direct and transcriptional manner.
Alternative Names
PDK4 ; FLJ40832
Tag
N-GST tag
Quantity
10 µg
Regulatory
RUO
Source
Insect cells
Host
Human
Biological Activity Comment
The specific activity of PDHK4 was determined to be20 nmol /min/mg as per activity assay protocol.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.