PDGFRa (platelet-derived growth factor receptor a) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRa has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRa in renal cell types involved in fibrotic and sclerosing processes . PDGF and its receptor PDGFRa are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase .
Alternative Names
CD140A ; PDGFR2 ; MGC74795 ; Rhe-PDGFRA
Tag
N-GST tag
Quantity
10 µg
Regulatory
RUO
Source
Insect cells
Host
Human
Biological Activity Comment
The specific activity of PDGFRa was determined to be 12 nmol /min/mg as per activity assay protocol.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Immunogen Species
Homo Sapiens (Human)
Reviews of Recombinant Human PDGFR alpha (N-GST tag)