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Home / Proteins & Peptide

Recombinant Human PDGFA

SKU : BHP10900414

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z103015
Description	The PDGF family is comprised of five different disulphide-linked dimers of four different polypeptide chains: A, B, C and D (PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD). Synthesized mainly by megakaryocytes, PDGFs are stored in the alpha granules of platelets from which they are released following platelet activation. PDGF receptors are expressed in fibroblasts, osteoblasts, chondroblasts, smooth muscle cells, glial cells and endothelial cells. Functioning as an autocrine and paracrine growth factor, PDGFs are involved in a number of biological processes that include but not limited to hyperplasia, chemotaxis, embryonic neuron development, wound healing and respiratory tubule epithelial cell development. Aberrant expression of PDGFs is observed with vascular proliferative diseases such as atherosclerosis. PDGFs regulate the synthesis of their own receptor and also influence the expression of membrane receptors for IL1, EGF, 5-Hydroxytryptamine, LDL and transferrin. Recombinant Human PDGFA expressed in human 293 cells is a mixture of pro-dimers, pro-mature and mature dimers with a molecular mass of 35 to 45 kDa.
Alternative Names	PDGFaa ; PDGF subunit A ; PDGF-1 ; Platelet-derived growth factor A chain ; Platelet-derived growth factor alpha polypeptide ; PDGFA ; PDGF-AA ; PDGF1
Quantity	10 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose-dependent stimulation of the proliferation of 3T3 cells was found to be ≤25 ng/mL.

Weight	35, 40 and 45 kDa, homodimer, glycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 10 mM HOAc containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 10 mM HOAc
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900414	Z103015	10µg	$344.44		Add to Cart

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