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Home / Proteins & Peptide

Recombinant Human PDCD1/PD-1/CD279 (C-6His-Avi) Biotinylated

SKU : BHP10304791

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033853
Alternative Names	Programmed cell death protein 1; hPD-1; PDCD1; CD279
Reconstitution	Please refer to the printed manual for detailed information.
Background	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Reactivity	Human
Tag	C-6His-Avi
Description	Biotinylated Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Pro21-Gln167 is expressed with a 6His, Avi tag at the C-terminus.
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Host	Human Cells
Accession Number	Q15116
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	19.2 kDa
Mw(kda)	19.2 kDa

Sequence Info	Pro21-Gln167

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304791	PKSH033853	20ug	$342		Add to Cart
BHP10304791	PKSH033853	100ug	$924		Add to Cart

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