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Home / Proteins & Peptide

Recombinant Human PD-1/PDCD1 Protein (C93S Mutant, His Tag)

SKU : BHP10303878

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH032862
Description	Recombinant Human Programmed Cell Death Protein 1 mutant(C93S) is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167;Cys93Ser is expressed with a 6His tag at the C-terminus.
Alternative Names	Programmed cell death protein 1;PDCD1;PD-1;hPD-1;CD279;SLEB2;Hsle1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition; coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule; PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function.
Reactivity	Human
Tag	C-6His
Formulation	Lyophilized from a 0.2 um filtered solution of PBS; pH 7.4.
Host	Human Cells
Accession Number	Q15116
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	16.8 kDa
Mw(kda)	16.8 kDa

Sequence Info	Leu25-Gln167;Cys93Ser

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303878	PKSH032862	10ug	$129		Add to Cart
BHP10303878	PKSH032862	50ug	$375		Add to Cart

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