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Home / Proteins & Peptide

Recombinant Human PCNA-associated factor(PCLAF)

SKU : BHP10500672

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP012164HU
Alternative Names	Hepatitis C virus NS5A-transactivated protein 9 ,HCV NS5A-transactivated protein 9Overexpressed in anaplastic thyroid carcinoma 1 ,OEATC-1,PCNA-associated factor of 15 kDa ,PAF15 ,p15PAF, Hepatitis C virus NS5A-transactivated protein 9 ; HCV NS5A-transactivated protein 9Overexpressed in anaplastic thyroid carcinoma 1 ; OEATC-1 ; PCNA-associated factor of 15 kDa ; PAF15 ; p15PAF
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-111aa
Mol Weight	39.0kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus, Cytoplasm, perinuclear region
Uniprot	Q15004, Q15004
Database Links	HGNC:28961 OMIM:610696 KEGG:hsa:9768 STRING:9606.ENSP00000300035 UniGene:Hs.81892
Function	PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Pathway	Inflammatory Pain
Tissue Specificity	Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer l
Weight	39.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500672	CSB-EP012164HU	1mg	$1812		Add to Cart
BHP10500672	CSB-EP012164HU	100ug	$419		Add to Cart
BHP10500672	CSB-EP012164HU	20ug	$224		Add to Cart

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