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Home / Proteins & Peptide

Recombinant Human papillomavirus type 18 Regulatory protein E2(E2)

SKU : BHP10501213

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP361949HMN
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	E2 regulates viral transcription and DNA replication. It binds to the E2RE response elent (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elents. Repression occurs by sterically hindering the assbly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-365aa
Mol Weight	45.3 kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Host nucleus
Uniprot	P06790, P06790
Function	Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Protein Families	Papillomaviridae E2 protein family
Research Area	Epigenetics and Nuclear Signaling
Weight	45.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501213	CSB-EP361949HMN	1mg	$1812		Add to Cart
BHP10501213	CSB-EP361949HMN	100ug	$419		Add to Cart
BHP10501213	CSB-EP361949HMN	20ug	$224		Add to Cart

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