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Home / Proteins & Peptide

Recombinant Human Na(+)/H(+) exchange regulatory cofactor NHE-RF3(PDZK1)

SKU : BHP10501356

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP722565HU
Alternative Names	CFTR-associated protein of 70 kDaNa(+)/H(+) exchanger regulatory factor 3Na/Pi cotransporter C-terminal-associated protein 1 ,NaPi-Cap1,PDZ domain-containing protein 1Sodium-hydrogen exchanger regulatory factor 3, CFTR-associated protein of 70 kDaNa(+)/H(+) exchanger regulatory factor 3Na/Pi cotransporter C-terminal-associated protein 1 ; NaPi-Cap1 ; PDZ domain-containing protein 1Sodium-hydrogen exchanger regulatory factor 3
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	A scaffold protein that connects plasma mbrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated mbrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma mbrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-519aa
Mol Weight	61.1kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Membrane, Peripheral membrane protein, Cell membrane
Uniprot	Q5T2W1, Q5T2W1
Database Links	HGNC:8821 OMIM:603831 KEGG:hsa:5174 STRING:9606.ENSP00000342143 UniGene:Hs.444751
Function	A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
Protein Families	NHER family
Research Area	Signal Transduction
Tissue Specificity	Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carci
Weight	61.2kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501356	CSB-EP722565HU	1mg	$1812		Add to Cart
BHP10501356	CSB-EP722565HU	100ug	$419		Add to Cart
BHP10501356	CSB-EP722565HU	20ug	$224		Add to Cart

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