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Home / Proteins & Peptide

Recombinant Human Muscle, skeletal receptor tyrosine-protein kinase(MUSK),partial (Active)

SKU : BHP10506156

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-CF015241HU
Alternative Names	Muscle-specific tyrosine-protein kinase receptor
Relevance	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation
Source	in vitro E.coli expression system
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Bioactivity	Measured by ADP-Glo Kinase detection kit. The EC50 of MUSK is 2.65-3.58 μg/ml.
Expression Region	24-495aa
Mol Weight	56.5kDa
Protein Description	Extracellular Domain

Involvement In Disease	Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency (CMS9); Fetal akinesia deformation sequence (FADS)
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane, Single-pass type I membrane protein
Uniprot	O15146
Database Links	HGNC:7525 OMIM:208150 KEGG:hsa:4593 STRING:9606.ENSP00000363571 UniGene:Hs.521653
Function	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle
Protein Families	Protein kinase superfamily, Tyr protein kinase family
Research Area	Signal Transduction

Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Storage Buffer	Tris-based buffer，50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10506156	CSB-CF015241HU	100ug	$1420		Add to Cart
BHP10506156	CSB-CF015241HU	20ug	$878		Add to Cart

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