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Home / Proteins & Peptide

Recombinant Human Mucosal addressin cell adhesion molecule 1(MADCAM1),partial

SKU : BHP10503073

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP618776HU
Alternative Names	, MAdCAM-1, hMAdCAM-1, MAdCAM-1 ; hMAdCAM-1
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	19-317aa
Mol Weight	47.4kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Membrane, Single-pass type I membrane protein
Uniprot	Q13477, Q13477
Database Links	HGNC:6765 OMIM:102670 KEGG:hsa:8174 STRING:9606.ENSP00000215637 UniGene:Hs.102598
Function	Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Research Area	Immunology
Tissue Specificity	Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ov
Weight	47.39kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503073	CSB-EP618776HU	1mg	$1812		Add to Cart
BHP10503073	CSB-EP618776HU	100ug	$419		Add to Cart
BHP10503073	CSB-EP618776HU	20ug	$224		Add to Cart

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