MMP-2 belongs to a family of endoproteases which need calcium and zinc in order to exert their catalytic capability (extracellular matrix remodeling). The elevated expression of these enzymes has been linked to many degenerative disorders, such as arthritis, cancer metastasis and skeletal growth-plate disorders. It has been shown that MMP-2 associates with many connective tissue cells as well as neutrophils, macrophages and monocytes.
Alternative Names
72 kDa type IV collagenase ; 72 kDa gelatinase ; Gelatinase A ; TBE-1 ; MMP-2
Quantity
10 µg
Regulatory
RUO
Source
E. coli
Host
Human
Endotoxin Level
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Weight
62.0 kDa
Format
Lyophilized PowderSupplied as a 0.2 μm filtered solution in Tris, CaCl2, NaCl and Brij35
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.