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Home / Proteins & Peptide

Recombinant Human MLK3 (N-GST tag)

SKU : BHP10900500

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500229
Description	MLK3 or Mixed-Lineage Kinase 3 is a mitogen-activated protein kinase kinase kinase capable of preferentially activating MAPK8/JNK kinase and functions as a positive regulator of JNK signaling pathway . MLK3 can directly phosphorylate and activate IkappaB kinase a and ß, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. MLK3 is a signal-integrating kinase with conventional MAP3K catalytic activity and additional noncatalytic functions that contribute to RAF/ERK signalling . MLK3 is a component of the BRAF/RAF1 complex and is required for integrity of the complex and for activation of ERK by the complex.
Alternative Names	MGC17114 ; MLK-3 ; MAP3K11 ; PTK1 ; SPRK ; MLK3
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of MLK3 was determined to be 9.5 nmol /min/mg as per activity assay protocol.

Weight	83.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900500	Z500229	10µg	$361.11		Add to Cart

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