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Home / Proteins & Peptide

Recombinant Human Mitogen-activated protein kinase 9(MAPK9)

SKU : BHP10500722

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP013471HU
Alternative Names	JNK-55Stress-activated protein kinase 1a ,SAPK1a,Stress-activated protein kinase JNK2c-Jun N-terminal kinase 2, JNK-55Stress-activated protein kinase 1a ; SAPK1a ; Stress-activated protein kinase JNK2c-Jun N-terminal kinase 2
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular domain stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-424aa
Mol Weight	64.1kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Nucleus
Uniprot	P45984, P45984
Database Links	HGNC:6886 OMIM:602896 KEGG:hsa:5601 STRING:9606.ENSP00000389338 UniGene:Hs.484371
Function	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock
Pathway	cAMP signaling pathway; ErbB signaling pathway; MAPK signaling pathway; Wnt signaling pathway; Focal adhesion; TNF signaling pathway; Apoptosis; Autophagy; Necroptosis; Protein processing in endoplasmic reticulum; Ras signaling pathway; Fc epsilon RI signaling pathway; IL-17 signaling pathway; NOD-like receptor signaling pathway; Osteoclast differentiation; T cell receptor signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Toll-like receptor signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; ER Stress pathway; FoxO signaling pathway; Insulin signaling pathway; Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Research Area	Signal Transduction
Weight	64.11kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500722	CSB-EP013471HU	1mg	$1812		Add to Cart
BHP10500722	CSB-EP013471HU	100ug	$419		Add to Cart
BHP10500722	CSB-EP013471HU	20ug	$224		Add to Cart

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