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Recombinant Human Mitogen-activated protein kinase 13(MAPK13)

SKU : BHP10500719

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP013452HU
Alternative Names	Mitogen-activated protein kinase p38 delta ,MAP kinase p38 delta,Stress-activated protein kinase 4, Mitogen-activated protein kinase p38 delta ; MAP kinase p38 delta ; Stress-activated protein kinase 4
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by Extracellular domain stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal rodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Mitogen-activated protein kinase 13; Short name= MAP kinase 13; Short name= MAPK 13; EC= 2.7.11.24; Alternative name(s): Mitogen-activated protein kinase p38 delta; Short name= MAP kinase p38 delta; Stre
Expression Region	1-365aa
Mol Weight	58.1kDa
Nature	recombinant
Protein Description	Full Length

Uniprot	O15264, O15264
Database Links	HGNC:6875 OMIM:602899 KEGG:hsa:5603 STRING:9606.ENSP00000211287 UniGene:Hs.178695
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Pathway	MAPK signaling pathway; VEGF signaling pathway; TNF signaling pathway; Cellular senescence; Signaling pathways regulating pluripotency of stem cells; Fc epsilon RI signaling pathway; IL-17 signaling pathway; Leukocyte transendothelial migration; NOD-like receptor signaling pathway; Osteoclast differentiation; T cell receptor signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Toll-like receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications; FoxO signaling pathway; Rap1 signaling pathway; Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Research Area	Cell Biology
Tissue Specificity	Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Weight	58.06kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500719	CSB-EP013452HU	1mg	$1812		Add to Cart
BHP10500719	CSB-EP013452HU	100ug	$419		Add to Cart
BHP10500719	CSB-EP013452HU	20ug	$224		Add to Cart

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