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Home / Proteins & Peptide

Recombinant Human Mitochondrial intermembrane space import and assembly protein 40(CHCHD4)

SKU : BHP10501481

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP850802HU
Alternative Names	Coiled-coil-helix-coiled-coil-helix domain-containing protein 4
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermbrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay syst.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-142aa
Mol Weight	32.0kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Mitochondrion intermembrane space
Uniprot	Q8N4Q1, Q8N4Q1
Database Links	HGNC:26467 OMIM:611077 KEGG:hsa:131474 STRING:9606.ENSP00000295767 UniGene:Hs.517815
Function	Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1
Research Area	Transport
Tissue Specificity	Expressed in all tissues tested, suggesting an ubiquitous expression.
Weight	32kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501481	CSB-EP850802HU	1mg	$1812		Add to Cart
BHP10501481	CSB-EP850802HU	100ug	$419		Add to Cart
BHP10501481	CSB-EP850802HU	20ug	$224		Add to Cart

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