MIA is a secreted, regulatory protein produced mainly by chondrocytes and malignant melanoma cells. This protein induces the metastasis of cancer cells by indirectly causing the detachment of melanoma cells from the surrounding extracellular matrix. MIA levels are now measured and used as a diagnostic tool for melanoma metastasis and rheumatoid arthritis.
Alternative Names
Cartilage-derived retinoic acid-sensitive protein ; CD-RAP ; Melanoma inhibitory activity protein
Quantity
1.0 mg
Regulatory
RUO
Source
E. coli
Host
Human
Endotoxin Level
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Biological Activity Comment
N.A.
Weight
12.4 kDa
Description
Reconstitute at 100 μg/mL in sterile PBS
Format
Lyophilized PowderLyophilized from a 0.2 μm filtered solution in PBS
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.