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Home / Proteins & Peptide

Recombinant Human Methionine aminopeptidase 2(METAP2)

SKU : BHP10502391

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP013716HU
Alternative Names	Initiation factor 2-associated 67 kDa glycoprotein
Antigen	METAP2
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Cotranslationally roves the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Methionine aminopeptidase 2; Short name= MAP 2; Short name= MetAP 2; EC= 3.4.11.18; Alternative name(s): Initiation factor 2-associated 67 kDa glycoprotein; Peptidase M 2; p67eIF2; Short name= p67
Expression Region	2-478aa
Mol Weight	54.8kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Cytoplasm
Uniprot	P50579, P50579
Database Links	HGNC:16672 OMIM:601870 KEGG:hsa:10988 STRING:9606.ENSP00000325312 UniGene:Hs.444986
Function	Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION
Protein Families	Peptidase M24A family, Methionine aminopeptidase eukaryotic type 2 subfamily
Research Area	Metabolism
Weight	54.7kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502391	CSB-YP013716HU	500ug	$1298		Add to Cart
BHP10502391	CSB-YP013716HU	100ug	$470		Add to Cart
BHP10502391	CSB-YP013716HU	20ug	$250		Add to Cart

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