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Home / Proteins & Peptide

Recombinant Human MELK (1-550aa) (N-GST tag)

SKU : BHP10900618

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500223
Description	MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells . MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL . Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers.
Alternative Names	HPK38 ; KIAA0175
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of MELK was determined to be 210 nmol /min/mg as per activity assay protocol.

Weight	88.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900618	Z500223	10µg	$361.11		Add to Cart

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