MEK6 or MAP2K6(mitogen-activated protein kinase kinase 6) is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase that also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MEK6 phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress . As an essential component of p38 MAP kinase mediated signal transduction pathway, MEK6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis .
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.