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Home / Proteins & Peptide

Recombinant Human Mediator of DNA damage checkpoint protein 1(MDC1),partial

SKU : BHP10503149

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP623929HU
Alternative Names	Nuclear factor with BRCT domains 1
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Nuclear factor with BRCT domains 1
Expression Region	1892-2082aa
Mol Weight	36.9 kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Nucleus, Chromosome
Uniprot	Q14676, Q14676
Database Links	HGNC:21163 OMIM:607593 KEGG:hsa:9656 STRING:9606.ENSP00000365588 UniGene:Hs.653495
Function	Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
Tissue Specificity	Highly expressed in testis.
Weight	36.91kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503149	CSB-EP623929HU	1mg	$2466		Add to Cart
BHP10503149	CSB-EP623929HU	100ug	$578		Add to Cart
BHP10503149	CSB-EP623929HU	20ug	$306		Add to Cart

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