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Home / Proteins & Peptide

Recombinant Human MARK4 (N-GST tag)

SKU : BHP10901172

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500212
Description	MARK4 or microtubule affinity-regulating kinase 4 is a member of the Par-1 family of serine/threonine protein kinases. MARK4 is predominantly expressed in the brain and readily phosphorylates Tau, MAP2 and MAP4. MARK4 co-localizes with the centrosome and microtubules in cultured cells. Overexpression of MARK4 causes thinning out of the microtubule network concomitant with the reorganization of microtubules into bundles . MARK4 provides a growth advantage to cells and the up-regulation of this kinase during focal ischaemia may represent an interesting new target for pharmacological intervention. MARK4 is expressed during the cell cycle and is linked to aberrant centrosomes in glioma cells .
Alternative Names	MARKL1 ; KIAA1860
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of MARK4 was determined to be1,050 nmol /min/mg as per activity assay protocol.

Weight	104.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901172	Z500212	10µg	$361.11		Add to Cart

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