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Home / Proteins & Peptide

Recombinant Human M-CSF/CSF1 Protein (Active)

SKU : BHP10303097

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031969
Description	A DNA sequence encoding the human CSF1 (NP_757349.1) (Met1-Asn190) was expressed with an initial Met.
Alternative Names	Macrophage Colony-Stimulating Factor 1; CSF-1; M-CSF; MCSF; Lanimostim; CSF1;SCF-1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
Reactivity	Human
Formulation	Lyophilized from sterile PBS, pH 7.4.
Host	HEK293 Cells
Accession Number	NP_757349.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Measured in a cell proliferation assay using M?NFS?60 mouse myelogenous leukemia lymphoblast cells.The ED50 for this effect is typically 1.6-6.3 ng/mL.
Mol Weight	18.4 kDa
Mw(kda)	18.4 kDa

Sequence Info	Met 1-Asn190

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 85 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303097	PKSH031969	20ug	$363		Add to Cart

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