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Recombinant Human Low-density lipoprotein receptor-related protein 4(LRP4),partial

SKU : BHP10503526

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP013099HU
Alternative Names	Multiple epidermal growth factor-like domains 7
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alteatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and intealizing extracellular ligands for degradation by lysosomes.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Low-density lipoprotein receptor-related protein 4; Short name= LRP-4; Alteative name(s): Multiple epidermal growth factor-like domains 7
Mol Weight	19.9kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Cenani-Lenz syndactyly syndrome (CLSS); Sclerosteosis 2 (SOST2); Myasthenic syndrome, congenital, 17 (CMS17)
Subcellular Location	Cell membrane, Single-pass type I membrane protein
Uniprot	O75096, O75096
Database Links	HGNC:6696 OMIM:212780 KEGG:hsa:4038 STRING:9606.ENSP00000367888 UniGene:Hs.4930
Function	Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alteatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and intealizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).
Protein Families	LDLR family
Research Area	Others
Tissue Specificity	Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain.
Weight	19.9kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503526	CSB-YP013099HU	500ug	$1916		Add to Cart
BHP10503526	CSB-YP013099HU	100ug	$694		Add to Cart
BHP10503526	CSB-YP013099HU	20ug	$368		Add to Cart

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