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Home / Proteins & Peptide

Recombinant Human Long R3 Insulin-like Growth factor-1 (rHuLR3IGF-1)

SKU : BHP11300338

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Mfr.No.	PR1080
Description	Insulin-like growth factor-1 (IGF-1) is the principal hormonal mediator of statural growth. Under normal circumstances, growth hormone (GH) binds to its receptor in the liver, and other tissues, and stimulates the synthesis/secretion of IGF-1. In target tissues, the Type 1 IGF receptor, which is homologous to the insulin receptor, is activated by IGF-1, leading to intracellular signaling which stimulates multiple processes leading to statural growth. The metabolic actions of IGF-1 are in part directed at stimulating the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues. The LR3 is a long-term analog of human IGF-1, specifically designed and manufactured for mammalian cell culture to support large-scale manufacturing of recombinant biopharmaceuticals.
Regulatory	RUO
Source	Escherichia coli.
Host	Human
Endotoxin Level	Less than 5EU/100mg of rHuLR3IGF-1 as determined by LAL method.
Biological Activity Comment	Fully biologically active when compared to standard. The ED50 as determined by the stimulation of protein synthesis in L6 myoblasts is less then 10 ng/ml, corresponding to a Specific Activity of ＞1 x 105 IU/mg.
Nature	Recombinant

Weight	Approximately 9.1 kDa, a single non-glycosylated polypeptide chain containing 83 amino acids.

Description	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Format	Lyophilized from a 0.2mm filtered concentrated solution in 20mM PB, pH 7.2. Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	>85% by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP11300338	PR1080	20μg	$205.56		Add to Cart
BHP11300338	PR1080	100μg	$383.33		Add to Cart

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