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Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 5(LGR5),partial

SKU : BHP10502373

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP012906HU
Alternative Names	G-protein coupled receptor 49G-protein coupled receptor 67G-protein coupled receptor HG38
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a st cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by Extracellular domain Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal st cells during postbryonic development.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Leucine-rich repeat-containing G-protein coupled receptor 5; Alternative name(s): G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
Expression Region	22-561aa
Mol Weight	62.4kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Cell membrane, Multi-pass membrane protein, Golgi apparatus, trans-Golgi network membrane, Multi-pass membrane protein
Uniprot	O75473, O75473
Database Links	HGNC:4504 OMIM:606667 KEGG:hsa:8549 STRING:9606.ENSP00000266674 UniGene:Hs.658889
Function	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Protein Families	G-protein coupled receptor 1 family
Research Area	Cancer
Tissue Specificity	Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of th
Weight	62.37kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502373	CSB-YP012906HU	500ug	$1298		Add to Cart
BHP10502373	CSB-YP012906HU	100ug	$470		Add to Cart
BHP10502373	CSB-YP012906HU	20ug	$250		Add to Cart

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