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Home / Proteins & Peptide

Recombinant Human LATS1 (N-GST tag)

SKU : BHP10901179

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500195
Description	LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding . LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments .
Alternative Names	WARTS ; wts
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of LATS1 was determined to be 1.4 nmol /min/mg as per activity assay protocol.

Weight	95.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901179	Z500195	10µg	$361.11		Add to Cart

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