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Home / Proteins & Peptide

Recombinant Human KRAS4B(G12V, N-6His)

SKU : BHP10304890

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033952
Description	Recombinant Human GTPase Kras4B is produced by our E.coli expression system and the target gene encoding Met1-Lys169 is expressed with a 6His tag at the N-terminus.
Alternative Names	Ki-Ras; c-K-ras; KRAS2; RASK2; CFC2
Reconstitution	Please refer to the printed manual for detailed information.
Background	K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome{4} and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.
Reactivity	Human
Tag	N-6His
Formulation	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Host	E.coli
Accession Number	P01116-2
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	21.4 kDa
Mw(kda)	21.4 kDa

Sequence Info	Met1-Lys169

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	>95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304890	PKSH033952	10ug	$79		Add to Cart
BHP10304890	PKSH033952	50ug	-		Add to Cart

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