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Recombinant Human Kit ligand(KITLG),partial (Active)

BHP10506226
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Involvement In Disease Hyperpigmentation with or without hypopigmentation, familial progressive (FPHH); Deafness, congenital, unilateral or asymmetric (DCUA)
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Single-pass type I membrane protein, Cell projection, lamellipodium, Cell projection, filopodium, SUBCELLULAR LOCATION: Soluble KIT ligand: Secreted
Uniprot P21583
Database Links

HGNC:6343

OMIM:145250

KEGG:hsa:4254

STRING:9606.ENSP00000228280

UniGene:Hs.1048
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Pathway MAPK signaling pathway; Melanogenesis; PI3K-Akt signaling pathway; Ras signaling pathway; Fc gamma R-mediated phagocytosis; Phospholipase D signaling pathway; Rap1 signaling pathway
Protein Families SCF family
Research Area Immunology
Purity Greater than 95% as determined by SDS-PAGE.
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.0
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10506226 CSB-AP003741HU 1mg $3402
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BHP10506226 CSB-AP003741HU 500ug $2170
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BHP10506226 CSB-AP003741HU 50ug $360
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