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Home / Proteins & Peptide

Recombinant Human Kallikrein 6/KLK6 Protein (His Tag)(Active)

SKU : BHP10302839

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030894
Description	A DNA sequence encoding the human KLK6 isoform 1 (Q92876-1) (Met 1-Lys 244), was fused with a polyhistidine tag at the C-terminus.
Alternative Names	Kallikrein-6; Neurosin; Protease M; SP59; Serine Protease 18; Serine Protease 9; Zyme; KLK6; PRSS18; PRSS9
Reconstitution	Please refer to the printed manual for detailed information.
Background	KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	Q92876-1
Endotoxin Level	< 1.0 EU per ug of the protein as determined by the LAL method.
Bioactivity	Measured by its ability to cleave the fluorogenic peptide substrate Boc-QARAMC, R&D Systems, Catalog # ES014.The specific activity is > 250 pmols/min/ug.(Activation description: The proenzyme needs to be activated by Lysyl-Endopeptidase for an activated form)
Mol Weight	26.6 kDa
Mw(kda)	26.6 kDa

Sequence Info	Met 1-Lys 244

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302839	PKSH030894	50ug	$867		Add to Cart

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