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Home / Proteins & Peptide

Recombinant Human ITK (N-GST tag)

SKU : BHP10900510

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500183
Description	ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor. ITK requires prior activation of LCK, ZAP70 and PI3-kinase for efficient activation and shares major substrates with both LCK and ZAP70 . ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization .
Alternative Names	LYK ; PSCTK2 ; MGC126257 ; MGC126258 ; EMT
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of ITK was determined to be 50nmol /min/mg as per activity assay protocol.

Weight	108.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900510	Z500183	10µg	$361.11		Add to Cart

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