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Home / Proteins & Peptide

Recombinant Human Interleukin-22 receptor subunit alpha-1(IL22RA1),partial

SKU : BHP10501420

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP822717HU
Alternative Names	Cytokine receptor class-II member 9Cytokine receptor family 2 member 9 ,CRF2-9ZcytoR11, Cytokine receptor class-II member 9Cytokine receptor family 2 member 9 ; CRF2-9ZcytoR11
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	250-573aa
Mol Weight	50.8kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Membrane, Single-pass type I membrane protein
Uniprot	Q8N6P7, Q8N6P7
Database Links	HGNC:13700 OMIM:605457 KEGG:hsa:58985 STRING:9606.ENSP00000270800 UniGene:Hs.110915
Function	Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Pathway	Jak-STAT signaling pathway
Protein Families	Type II cytokine receptor family
Research Area	Immunology
Tissue Specificity	Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial
Weight	50.8kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501420	CSB-EP822717HU	1mg	$1812		Add to Cart
BHP10501420	CSB-EP822717HU	100ug	$419		Add to Cart
BHP10501420	CSB-EP822717HU	20ug	$224		Add to Cart

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