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Recombinant Human Interleukin-1 receptor antagonist protein(IL1RN) (Active)

BHP10506466
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Involvement In Disease Microvascular complications of diabetes 4 (MVCD4); Interleukin 1 receptor antagonist deficiency (DIRA)
Subcellular Location Isoform 1: Secreted, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, SUBCELLULAR LOCATION: Isoform 4: Cytoplasm
Uniprot P18510
Database Links

HGNC:6000

OMIM:147679

KEGG:hsa:3557

STRING:9606.ENSP00000259206

UniGene:Hs.81134
Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Research Area Immunology
Tissue Specificity The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Purity Greater than 95% as determined by SDS-PAGE.
Storage Buffer Lyophilized from a 0.2 μm Filtered 50 mM Tris-HCl, 0.2 M NaCl, pH 7.5
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10506466 CSB-AP004601HU 1mg $1702
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BHP10506466 CSB-AP004601HU 500ug $1190
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BHP10506466 CSB-AP004601HU 50ug $194
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