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Recombinant Human Insulin-like growth factor I protein(IGF1),15N Stable Isotope Labeled (Active)

SKU : BHP10500186

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-AP002531HU
Alternative Names	IGF-I, MGF, Somatomedin-C, IGF-I ; MGF ; Somatomedin-C
Pubmed Id	6358902; 3002851; 2935423; 2937782; 3455760; 2082190; 2018498; 1372070; 8495408; 16541075; 15489334; 6382022; 632300; 3242681; 21076856; 24132240; 6189745; 2036417; 1319992; 8857020; 10391209
Regulatory	RUO
Source	E.coli
Endotoxin Level	Less than 1.0 EU/μg as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of >5.0x10⁵ IU/mg.
Expression Region	49-118aa
Mol Weight	7.7 kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Involvement In Disease	Insulin-like growth factor I deficiency (IGF1 deficiency)
Subcellular Location	Secreted
Uniprot	P05019, P05019
Database Links	HGNC:5464 OMIM:147440 KEGG:hsa:3479 STRING:9606.ENSP00000302665 UniGene:Hs.160562
Function	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation
Pathway	HIF-1 signaling pathway; MAPK signaling pathway; mTOR signaling pathway; p53 signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Ras signaling pathway; Signaling pathways regulating pluripotency of stem cells; AMPK signaling; FoxO signaling pathway; Rap1 signaling pathway
Protein Families	Insulin family
Research Area	Cancer
Weight	7743 Da

Buffer	0.2 µm filtered PBS, pH 7.0,lyophilized
Purity	>97% as determined by SDS-PAGE and HPLC.
Storage Buffer	0.2 μm filtered PBS, pH 7.0 ,lyophilized

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500186	CSB-AP002531HU	500ug	$1910		Add to Cart
BHP10500186	CSB-AP002531HU	100ug	$852		Add to Cart
BHP10500186	CSB-AP002531HU	10ug	$142		Add to Cart

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