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Recombinant Human Insulin-like growth factor 1 receptor(IGF1R),partial

BHP10500637
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Email
[email protected]
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Involvement In Disease Insulin-like growth factor 1 resistance (IGF1RES)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Uniprot P08069, P08069
Database Links

HGNC:5465

OMIM:147370

KEGG:hsa:3480

STRING:9606.ENSP00000268035

UniGene:Hs.643120
Function Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways
Pathway HIF-1 signaling pathway; MAPK signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Adherens junction; Autophagy; Ras signaling pathway; Signaling pathways regulating pluripotency of stem cells; AMPK signaling; FoxO signaling pathway; Rap1 signaling pathway; Endocytosis
Protein Families Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the
Weight 35.42kDa
Stotage Note Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer Tris-based buffer，50% glycerol
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10500637 CSB-EP011087HU 1mg $1812
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BHP10500637 CSB-EP011087HU 100ug $419
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BHP10500637 CSB-EP011087HU 20ug $224
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