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Home / Proteins & Peptide

Recombinant Human InsR (N-GST tag)

SKU : BHP10901125

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500179
Description	InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, a and ß that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake . Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas ß cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult ß cells and the central control of nutrient homeostasis .
Alternative Names	HHF5 ; CD220
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of InsR was determined to be 2683 nmol /min/mg as per activity assay protocol.

Weight	70.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901125	Z500179	10µg	$361.11		Add to Cart

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