Recombinant Human Inactive tyrosine-protein kinase 7 (PTK7),partial

Mfr.No.	CSB-YP622651HU
Alternative Names	Colon carcinoma kinase 4 ,CCK-4Protein-tyrosine kinase 7Pseudo tyrosine kinase receptor 7Tyrosine-protein kinase-like 7, Colon carcinoma kinase 4 ; CCK-4Protein-tyrosine kinase 7Pseudo tyrosine kinase receptor 7Tyrosine-protein kinase-like 7
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in bryogenesis, epithelial tissue organization and angiogenesis.
Source	Yeast
Abbreviation	PTK7
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Inactive tyrosine-protein kinase 7; Alternative name(s): Colon carcinoma kinase 4; Short name= CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7
Expression Region	31-704aa
Mol Weight	76.6kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Membrane, Single-pass type I membrane protein, Cell junction
Uniprot	Q13308, Q13308
Database Links	HGNC:9618 OMIM:601890 KEGG:hsa:5754 STRING:9606.ENSP00000230419 UniGene:Hs.90572
Function	Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Protein Families	Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Research Area	Cell Adhesion
Tissue Specificity	Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Weight	76.6kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol