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Home / Proteins & Peptide

Recombinant Human IL37 (IL1F7)

SKU : BHP10900421

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102885
Description	Member of the IL-1 family, IL-37 functions to curb excessive inflammation. In partnership with SMAD3, IL-37 suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Out of the five isoforms for IL-37 (a-e), this product represents isoform B that is expressed in testis, colon, placenta, lung and lymph node similar to isoform A and C but is the only one found in kidneys. Recombinant Human IL37/IL23 expressed in human 293 cells is a heterodimeric glycoprotein composed of two disulfide-linked subunits (p40 cystine linked to p19) with a molecular mass of 55 kDa.
Alternative Names	IL-1X ; Interleukin-1 family member 7 ; IL-1F7 ; Interleukin-1 homolog 4 ; IL-1H ; IL-1H4 ; Interleukin-1 zeta ; IL-1 zeta ; Interleukin-1-related protein ; IL-1RP1 ; IL-37 ; IL-23 ; FIL1 zeta
Quantity	10 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dosedependent secretion of IL-17 in response to IL-23 using murine splenocytes was found to be ≤ 30 ng/mL.

Weight	55 kDa, heterodimer, glycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 1x PBS
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900421	Z102885	10µg	$417.50		Add to Cart

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