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Home / Proteins & Peptide

Recombinant Human IL36B

SKU : BHP10900904

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102467
Description	IL36B, also known as Interleukin 36 beta and IL1F8, is a cytokine belonging to the IL-1 family. It is actively secreted and is found to form a cytokine gene cluster on chromosome 2 with eight other IL1 cytokines. IL36B signals through the IL1Rrp2/IL-36R receptor on dendritic cells which then activates NFkB and MAPK signalling pathways to create a pro-inflammatory response. It stimulates the production of mature adipocytes, and IL6 and IL8 synovial fibroblasts. It also induces expression of some antimicrobial peptides and matrix metalloproteases. It is highly expressed in psoriatic plaques, as part of the IL36 signalling system is found in many epithelial barriers.
Alternative Names	FIL1 eta ; Interleukin-1 eta ; Interleukin-1 family member 8 ; Interleukin-1 homolog 2
Quantity	100 µg
Regulatory	RUO
Source	E. coli
Host	Human
Endotoxin Level	<1.0 EU/μg of recombinant protein as determined by the LAL method
Biological Activity Comment	IL-36 beta can bind to human IL-1 Rrp2 Fc Chimera with a linear range of 0.15-5 µg/mL as determined by its binding ability in a functional ELISA

Weight	17.5 kDa

Description	Reconstitute in sterile PBS at 100µg/mL (containing at least 0.1% human or bovine serum albumin)
Format	Lyophilized Powder Lyophilized from a 0.2 µm filtered solution in PBS (with BSA as a carrier protein)
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900904	Z102467	100µg	$264.44		Add to Cart

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