IL-1 epsilon is an actively secreted member of the IL-1 family of cytokines. It is mainly expressed in tissues with epithelial cells and in psoriatic plaques, as well as by monocytes, B cells and T cells. IL-1 epsilon has been shown to signal through the IL-Rrp2 receptor which is primarily expressed on certain denditic cells, and to act as an agonist of NF-kappaB which then stimulates the inflammatory response in bronchial epithelial cells.
Alternative Names
IL-1 Epsilon ; FIL1 epsilon ; Interleukin-1 family member 6 ; IL-1F6 ; IL-36 gamma ; IL-1F ; IL-1H1 Recombinant Human Interleukin-36 alpha (IL36A)
Appearance
Lyophilized Powder
Reconstitution
Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS, NaCl and Tween® 20 with BSA as a carrier protein
Molecular Weight
17.4 kDa
Quantity
20 µg
Source
E. coli
Usage
For research use only. Not for diagnostic or therapeutic use.
Accession Number
Q9UHA7
Endotoxin Level
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Bioactivity
Gel Image
Gene Id
27179
Gene Name
IL36A
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.Avoid repeated freeze/thaw cycles.