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Home / Proteins & Peptide

Recombinant Human IL27

SKU : BHP10900623

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102897
Description	IL27 is a cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL-17 producing helper T cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Recombinant Human IL-27 expressed in human 293 cells as a non-covalently bonded heterodimer cytokine composed of IL27p28 (25 kDa) and glycosylated EB13 (30 kDa).
Alternative Names	IL-27 subunit alpha ; IL-27-A ; IL27-A ; p28 ; Interleukin-27 subunit alpha
Quantity	100 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose-dependent inhibition of HIV replication in human CD4+ T cells and in human monocyte-derived macrophages was found to be ≤12 ng/mL.

Weight	25 and 30 kDa heterodimer,glycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 1x PBS
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900623	Z102897	100µg	$2685.50		Add to Cart

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