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Home / Proteins & Peptide

Recombinant Human IL1R2/CD121b Protein (His Tag)

SKU : BHP10304418

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033449
Description	Recombinant Human Interleukin-1 receptor type 2/IL-1R-2 is produced by our Mammalian expression system and the target gene encoding Phe14-Glu343 is expressed with a 6His tag at the C-terminus.
Alternative Names	CD121b;CDw121b;IL-1R-2;IL-1RT-2;IL-1RT2;IL1R2c;IL1RB;Interleukin-1 receptor type 2; IL-1R-2; CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta; Interleukin-1 receptor type I
Reconstitution	Please refer to the printed manual for detailed information.
Background	Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified; designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes; neutrophils; monocytes; large granular leukocytes and endothelial cells. IL1R2 is non-signaling receptor forIL1A; IL1B and IL1RN; reduces IL1B activities. IL1R2 serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Reactivity	Human
Tag	C-6His
Formulation	Lyophilized from a 0.2 um filtered solution of PBS; pH7.4.
Host	Human Cells
Accession Number	NP_004624.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	38.6 kDa
Mw(kda)	38.6 kDa

Sequence Info	Phe14-Glu343

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304418	PKSH033449	10ug	$117		Add to Cart
BHP10304418	PKSH033449	50ug	$297		Add to Cart

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