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Home / Proteins & Peptide

Recombinant Human IL1F6/IL36A Protein (His Tag)

SKU : BHP10302990

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031509
Description	A DNA sequence encoding the mature form of human IL1F6 (Q9UHA7) (Lys 6-Phe158) was expressed with a polyhistide tag at the N-terminus.
Alternative Names	Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6
Reconstitution	Please refer to the printed manual for detailed information.
Background	Interleukin-1 family member 6 (IL-1F6); also known as interleukin 36; alpha (IL36A); is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8; in addition to IL-1F9; activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta; suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line; NCI/ADR-RES; which naturally expresses IL-1Rrp2; all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6; IL-1F8; and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6; IL-1F8; and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.
Reactivity	Human
Tag	N-His
Formulation	Lyophilized from sterile PBS; pH 7.4
Host	E.coli
Accession Number	Q9UHA7
Endotoxin Level	Please contact us for more information.
Mol Weight	19.2 kDa
Mw(kda)	19.2 kDa

Sequence Info	Lys 6-Phe158

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 99 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302990	PKSH031509	20ug	$564		Add to Cart

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