IL19 belongs to the IL-10 family of proinflammatory cytokines, which is composed of IL10, IL19, IL20, IL22, IL24, and IL26. IL19 is mainly expressed in monocytes and binds to the IL20 receptor complex which leads to the activation of the signal transducer and activator of transcription 3 (STAT3). It also performs up-regulation of IL6 and TNF-alpha and apoptosis induction, thus signifying its role in inflammatory responses.
Alternative Names
Melanoma differentiation-association protein-like protein ; NG.1
Quantity
1.0 mg
Regulatory
RUO
Source
E. coli
Host
Human
Endotoxin Level
<1.0 EU/μg of recombinant protein as determined by the LAL method
Biological Activity Comment
The ED50 is 0.5-1.5 ng/mL as determined by a cell proliferation assay with the use of transfected BaF3 mouse pro-B cells with human IL-20Rα and human IL-20Rβ
Weight
18.0 kDa
Description
Reconstitute in sterile PBS at atleast 10µg/mL
Format
Lyophilized PowderLyophilized from a 0.2 µm filtered solution in PBS
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.