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Home / Proteins & Peptide

Recombinant Human IL-23(IL23A&IL12B) Protein (His Tag)(Active)

SKU : BHP10304572

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH033619
Description	Recombinant Human Interleukin-23 is produced by our Mammalian expression system and the target gene encoding Arg20-Pro189&Ile23-Ser328 is expressed with a 6His tag at the C-terminus.
Alternative Names	SGRF;IL-23p19;CLMF p40;IL-12 subunit p40;NKSF2;IL-23;IL-23A;IL23P19;P19
Reconstitution	Please refer to the printed manual for detailed information.
Background	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Host	Human Cells
Accession Number	Q9NPF7&P29460
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Bioactivity	Measured by its ability to induce STAT reporter activity in 293F human embryonic kidney cells. The ED50 for this effect is 307.2 ng/ml .
Mol Weight	55.2 kDa
Mw(kda)	55.2 kDa

Sequence Info	Arg20-Pro189Ile23-Ser328

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10304572	PKSH033619	10ug	$178		Add to Cart
BHP10304572	PKSH033619	50ug	$523		Add to Cart

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