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Home / Proteins & Peptide

Recombinant Human IKK beta (N-GST tag)

SKU : BHP10900655

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500177
Description	IKKß is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKKß is stimulated by TNF and IL1 and IKKß forms a heterodimer that interacts with NIK . Overexpression of catalytically inactive IKKß blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKKß activity in vitro and in vivo by binding to IKKß to reduce ATP binding .
Alternative Names	IKKB ; NFKBIKB ; FLJ40509 ; IKK-beta ; MGC131801 ; IKK2 ; IKBKB
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of IKKß was determined to be 58 nmol /min/mg as per activity assay protocol.

Weight	105.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900655	Z500177	10µg	$361.11		Add to Cart

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